By including ivermectin in a large-scale trial like PRINCIPLE, we hope to generate robust evidence to determine how effective the treatment is against COVID-19, and whether there are benefits or harms associated with its use.’įollowing a screening questionnaire to confirm eligibility, participants enrolled in the study will be randomly assigned to receive a three-day course of ivermectin treatment. Professor Chris Butler, from the University Oxford’s Nuffield Department of Primary Care Health Sciences, Joint Chief Investigator of the PRINCIPLE trial, said, ‘Ivermectin is readily available globally, has been in wide use for many other infectious conditions so it’s a well-known medicine with a good safety profile, and because of the early promising results in some studies it is already being widely used to treat COVID-19 in several countries. Even though ivermectin is used routinely in some countries to treat COVID-19, there is little evidence from large-scale randomised controlled trials to demonstrate that it can speed up recovery from the illness or reduce hospital admission. Small pilot studies show that early administration with ivermectin can reduce viral load and the duration of symptoms in some patients with mild COVID-19. With known antiviral properties, ivermectin has been shown to reduce SARS-CoV-2 replication in laboratory studies. Ivermectin is a safe, broad spectrum antiparasitic drug which is in wide use globally to treat parasitic infections. The study has so far recruited more than 5,000 volunteers from across the UK. Led by the University of Oxford, PRINCIPLE is investigating treatments for people at more risk of serious illness from COVID-19 which can speed up recovery, reduce the severity of symptoms and prevent the need for hospital admission. Anyone eligible and with COVID-19 symptoms can join the trial from anywhere in the UK, either online, over the phone or via their health care professional.įrom today, ivermectin is being investigated in the UK as part of the Platform Randomised Trial of Treatments in the Community for Epidemic and Pandemic Illnesses (PRINCIPLE), the world’s largest clinical trial of possible COVID-19 treatments for recovery at home and in other non-hospital settings.For COVID-19, ivermectin has shown promising results as a potential treatment in small studies in humans.Ivermectin, a widely used antiparasitic drug, has been added to the trial and is being evaluated in participants from today.PRINCIPLE is one of UK Government’s national priority platform trials of COVID-19 treatments, and the world’s largest currently taking place in community settings looking for treatments at home.Michael Saag, a professor of medicine and infectious diseases at the University of Alabama at Birmingham, told the Guardian in January. “The drug doesn’t work against Covid-full stop,” Dr. Rand Paul (R-Ky.) claimed that federal researchers would not give ivermectin a fair shot because of “hatred” for Trump. Nonetheless, legislatures in Colorado, Florida, New Hampshire, Pennsylvania and elsewhere have introduced bills to prevent action against medical professionals who prescribe ivermectin. Ivermectin can also cause side effects if taken alongside some other medications. Food and Drug Administration has not approved ivermectin to treat Covid-19 in people or animals, and warns that the concentrated doses formulated for animals can be dangerous for humans, possibly causing nausea, low blood pressure, dizziness, loss of balance, seizures, coma or death. Some early studies suggested ivermectin might effectively treat or prevent Covid, though researchers later found many of these studies had methodological weaknesses. A different form of ivermectin is used to treat animals like horses and cows for parasites. Ivermectin is an inexpensive and widely available drug used to treat humans for parasitic infections like intestinal worms or head lice. The JAMA study collected data from a total of 490 patients from May 31 to October 25.
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